Endogenous Viral Etiology of Prion Diseases
نویسندگان
چکیده
منابع مشابه
Endogenous Viral Etiology of Prion Diseases
Transmissible spongiform encephalopathies (TSEs), or prion diseases, are a group of incurable neurodegenerative disorders, including Kuru and Creutzfeldt-Jakob disease in humans, “mad cow” disease in cattle, and scrapie in sheep. This paper presents structural, genetic, and evolutionary evidence supporting an endogenous TSE virus model that integrates the three major traditional views on the na...
متن کاملInvolvement of Endogenous Retroviruses in Prion Diseases
For millions of years, vertebrates have been continuously exposed to infection by retroviruses. Ancient retroviral infection of germline cells resulted in the formation and accumulation of inherited retrovirus sequences in host genomes. These inherited retroviruses are referred to as endogenous retroviruses (ERVs), and recent estimates have revealed that a significant portion of animal genomes ...
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Background and purpose: Sometimes, some symptoms do not respond to usual treatments, or are not justified by classical medicine. In such cases, Persian Medicine can be helpful to better understand and treat the diseases. Endogenous gases (wind or Rih) are among the causes that should be investigated. The purpose of this study was to introduce endogenous gases and etiology of their production i...
متن کاملPrion Diseases
Stanley Prusiner introduced the term prion (proteinaceous infectious particle) and proposed that the infectious agent in prion diseases is composed mainly or entirely of an abnormal conformation of an otherwise normal host-encoded glycoprotein called the prion protein (PrP)1. This hypothesis was initially greeted with great skepticism in the scientific community but then later was widely acknow...
متن کاملNeuropathology of prion diseases.
In prion diseases, neuropathology has remained the most important tool to give a definite diagnosis, and neuropathological research has contributed significantly to our current pathogenetic understanding. Immunohistochemistry for the disease-associated prion protein (PrP(Sc)) is indispensable for the neuropathological confirmation of prion diseases. The amount and distribution of PrP(Sc) deposi...
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ژورنال
عنوان ژورنال: Nature Precedings
سال: 2009
ISSN: 1756-0357
DOI: 10.1038/npre.2009.3887.1